Surfactant-stabilized Emulsion Increases Gentamicin Elution From Bone Cement
نویسندگان
چکیده
منابع مشابه
Gentamicin elution profile of SmartSet GHV Gentamicin Bone Cement
Introduction There is no doubt that, since the invention of artificial joint replacement, many thousands of people have enjoyed freedom from disabling pain and immobility. However, this remarkable success story is marred by the incidence of local sepsis following surgery, which can lead to prosthesis loosening and the need for revision surgery. In fact, deep wound infections are the most seriou...
متن کاملGentamicin in bone cement
OBJECTIVES The objective of this study is to determine an optimal antibiotic-loaded bone cement (ALBC) for infection prophylaxis in total joint arthroplasty (TJA). METHODS We evaluated the antibacterial effects of polymethylmethacrylate (PMMA) bone cements loaded with vancomycin, teicoplanin, ceftazidime, imipenem, piperacillin, gentamicin, and tobramycin against methicillin-sensitive Staphyl...
متن کاملConcepts for increasing gentamicin release from handmade bone cement beads
BACKGROUND AND PURPOSE Commercial gentamicin-loaded bone cement beads (Septopal) constitute an effective delivery system for local antibiotic therapy. These beads are not available in all parts of the world, and are too expensive for frequent use in others. Thus, orthopedic surgeons worldwide make antibiotic-loaded beads themselves. However, these beads are usually not as effective as the comme...
متن کاملIn Vitro Elution Characteristics of Gentamicin and Vancomycin from Synthetic Bone Graft Substitutes
OBJECTS Beta tricalciumphosphate pellets loaded with individualized antibiotics may represent novel options in the treatment of osteomyelitis and infectious bone disease. Here, the in vitro antibiotic elution of vancomycin and gentamicin from the synthetic bone graft substitutes Cerasorb(®) and Cerasorb M(®) was tested. METHODS Antibiotic elution and concentration of gentamcin and vancomycin ...
متن کاملElution of metronidazole and gentamicin from polymethylmethacrylate beads.
OBJECTIVE To characterize the elution and bioactivity of metronidazole and gentamicin sulfate polymerized, individually and in combination, with polymethylmethacrylate (PMMA). STUDY DESIGN In vitro experimental study. METHODS PMMA beads containing metronidazole (3 concentrations), gentamicin sulfate, or metronidazole and gentamicin sulfate were immersed in 5 mL of phosphate-buffered saline ...
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ژورنال
عنوان ژورنال: Clinical Orthopaedics & Related Research
سال: 2011
ISSN: 0009-921X
DOI: 10.1007/s11999-011-1934-7